PHARMCOLOGICAL POTENTIAL OF GUDUCHYADI KWATHAM IN COMBATING COVID-19

  • Ansary Panamthanathil Yusuf Professor, Department of Dravyaguna, Govt. Ayurveda College, Thiruvananthapuram, Kerala.
  • Sudhikumar. K. B Professor, School of Fundamental Research in Ayurveda, Kerala University of Health Sciences, Trissur, Kerala, India.
Keywords: Guduchyadi kwatham, COVID-19, Viral infection, Respiratory symptoms.

Abstract

Guduchyadi kwatham is a renowned Ayurvedic formulation used by Ayurvedic physicians all over India against influenza attacks and viral diseases. It is indicated for Pitta and Kapha aggravated conditions, Jwaram (Fever) and diseases of gastrointestinal system in classical Ayurvedic literature. Indications and pharmacological activities of the ingredients in respiratory diseases and Rakta (Blood) vitiated conditions suggest the use of this formulation in viral diseases that mainly involve respiratory system. In order to assess the pharmacological potential, Ayurvedic literature of the formulation and the pharmacological evaluations conducted with the part used and phytoconstituents of individual drugs were collected. Informations about the pathogenesis and symptomatology of COVID-19 were gathered from the recent research publications which were available online. Common symptoms of Coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are fever, cough, sputum production, fatigue, headache, haemoptysis, diarrhoea, dyspnoea, and lymphopenia. When the disease progresses clinical conditions like Pneumonia, RNAaemia, acute respiratory distress syndrome, etc that lead to may develop death. Significantly increased level of leukocytes, pro-inflammatory cytokines and chemokines in plasma are seen during pathogenesis. The manifestation of systemic inflammatory response along with respiratory symptoms reveals that the main Doshas involved in this viral infection are Pitta and Kapha. The formulation possesses Pittakapha samana action and the ingredients are beneficial in diseases of Pranavahasrotas, Annavahasrotas, Rasavahasrotas and Raktavahasrotas. Pharmacological screening of drugs demonstrated anti-inflammatory, antipyretic, antiviral, antibacterial, anti allergic, antioxidant and immunomodulatory effects. Ayurvedic literature and findings of various phytochemical and pharmacological researches validate the use of Guduchyadi kwatham in the prevention and mitigation of this viral disease.

Author Biographies

Ansary Panamthanathil Yusuf, Professor, Department of Dravyaguna, Govt. Ayurveda College, Thiruvananthapuram, Kerala.

 

Dr. P. Y. Ansary, MD (Dravyagunavijnanam), PhD.

Also Dean, Faculty of Ayurveda, Siddha and Unani, Kerala University of Health Sciences, Trissur, Kerala. Has 23 yrs of under graduate and post-graduate teaching experience. Guide for MD and PhD in Kerala University of Health Sciences. Published more than 15 papers in research journals. More than 25 presentations in National and International seminars. Has been peer reviewer for international journals - Journal of Ayurveda and Integrative Medicine and Annals of Ayurvedic Medicine.

Sudhikumar. K. B, Professor, School of Fundamental Research in Ayurveda, Kerala University of Health Sciences, Trissur, Kerala, India.

 

Sudhikumar. K. B, Professor, School of Fundamental Research in Ayurveda, Kerala University of Health Sciences, Trissur, Kerala.

Dr. K. B. Sudhikumar, MD (Salyatantra)

Former Professor & HOD, Dept. of Salyatantra, Govt. Ayurveda College, Tripunithura, Kerala, Dean, Students Affairs,  Kerala University of Health Sciences, Trissur, Kerala.

Seminars- More than 100 presentations in National and International conference at Switzerland 1994. Notable presentations are Evidenced based leech application at Mumbai, Clinical application of Rasayana at KMC Manipal, Marma management Rastriya Ayurveda Vidyapeeth 2009, Sports injuries and management at National Susrutha Association, Role of massage in sports, Department of Indian Systems of Medicine Kerala, Role of Panchakarma in practice at Pune, Ministry of Small Scale Industries 2010.

Awards- Life Time Achievement Award by National Susrutha Association, Best Doctor Award “ Atreya Award” by Government of Kerala, Bharath Vidya Saraswathi Purskar by Gobel Achievers Foundation New Delhi.

Published
03-07-2020
How to Cite
Ansary Panamthanathil Yusuf, & Sudhikumar. K. B. (2020). PHARMCOLOGICAL POTENTIAL OF GUDUCHYADI KWATHAM IN COMBATING COVID-19. International Journal of Ayurveda and Pharma Research, 8(6), 9-22. Retrieved from http://ijaprs.com/index.php/ijapr/article/view/1455
Section
Articles