Experimental Study to Evaluate the Efficacy of Vishadan Tail in Dinitrofluorobenzene Induced Eczema in Albino Mice with reference to Dushivishjanya Vicharchika

Abstract

Vicharchika, a type of Kshudra Kushtha described in Ayurveda, closely resembles eczema in modern dermatology. It is a chronic inflammatory skin condition often triggered by impaired digestion and toxin accumulation (Ama), which may be linked to Dushivisha- subtle environmental and dietary toxins described in Ayurvedic texts. The present experimental study evaluates the efficacy of Vishadan Tail, a classical Ayurvedic formulation cited in Gadanigraha, for treating Dushivishjanya Vicharchika (eczema) using a DNFB-induced eczema model in Swiss albino mice. Mice were divided into four groups: normal control, disease control, standard (Betamethasone-treated), and Vishadan Tail-treated. The formulation, rich in herbs with Kusthaghna, Vishaghna, and Kandughna properties, was applied topically for 7 days. Macroscopic skin assessments and histopathological evaluations were performed. Results demonstrated a significant reduction in erythema, odema, and scaling in the Vishadan Tail group compared to the disease control group (p<0.001) with outcomes comparable to the standard treatment. Histopathology further confirmed reduced inflammation and cellular infiltration. The study concludes that Vishadan Tail exhibits promising therapeutic potential in the management of eczema, supporting its traditional claims and suggesting its possible use as a safe herbal alternative in dermatological care.